El Nadi, E., Elsherif, M., Elwakeel, M., Taha, H., Elshafiey, M., Ahmed, G., Zagloul, M., Elgalaly, D., Khaled, E., Ahmed, S. (2022). Vaginal Tumors in the Pediatric Age Group: The Children's Cancer Hospital Egypt (CCHE)-57357 Experience. Research in Oncology, 18(1), 10-18. doi: 10.21608/resoncol.2021.73214.1142
Enas El Nadi; Mariam Elsherif; Madeeha Elwakeel; Hala Taha; Maged Elshafiey; Gehad Ahmed; Mohamed S. Zagloul; Dina Elgalaly; Elham Khaled; Sahar Ahmed. "Vaginal Tumors in the Pediatric Age Group: The Children's Cancer Hospital Egypt (CCHE)-57357 Experience". Research in Oncology, 18, 1, 2022, 10-18. doi: 10.21608/resoncol.2021.73214.1142
El Nadi, E., Elsherif, M., Elwakeel, M., Taha, H., Elshafiey, M., Ahmed, G., Zagloul, M., Elgalaly, D., Khaled, E., Ahmed, S. (2022). 'Vaginal Tumors in the Pediatric Age Group: The Children's Cancer Hospital Egypt (CCHE)-57357 Experience', Research in Oncology, 18(1), pp. 10-18. doi: 10.21608/resoncol.2021.73214.1142
El Nadi, E., Elsherif, M., Elwakeel, M., Taha, H., Elshafiey, M., Ahmed, G., Zagloul, M., Elgalaly, D., Khaled, E., Ahmed, S. Vaginal Tumors in the Pediatric Age Group: The Children's Cancer Hospital Egypt (CCHE)-57357 Experience. Research in Oncology, 2022; 18(1): 10-18. doi: 10.21608/resoncol.2021.73214.1142
Vaginal Tumors in the Pediatric Age Group: The Children's Cancer Hospital Egypt (CCHE)-57357 Experience
1Department of Pediatric Oncology, Children's Cancer Hospital Egypt, Cairo, Egypt
2Medical Oncology Department, Faculty of Medicine, Beni‐Suef University, Beni-Suef, Egypt
3Department of Radiology, Children's Cancer Hospital Egypt, Cairo, Egypt
4National Cancer Institute, Cairo University, Cairo, Egypt
5Department of Pathology, Children's Cancer Hospital Egypt, Cairo, Egypt
6Department of Surgery, Children's Cancer Hospital Egypt, Cairo, Egypt
7Department of Surgery, Faculty of Medicine, Helwan University, Cairo, Egypt
8Department of Radiation Therapy, Children's Cancer Hospital Egypt, Cairo, Egypt
9Department of Research, Children's Cancer Hospital Egypt, Cairo, Egypt
Abstract
Background: Primary vaginal malignancies are rare in children. Their management has evolved during the last decades from radical surgery to neoadjuvant chemotherapy followed by local control with conservative surgery or radiotherapy. Aim: To describe the presentation, management, and outcome of pediatric vaginal malignancies. Methods: Retrospective review of the medical records of children with 1ry vaginal malignancies who had been treated at the Children’s Cancer Hospital Egypt (CCHE)-57357 from June 2007 till December 2018. Results: During the 11 years, 34 pediatric patients with 1ry vaginal malignancies were identified. The histopathology was rhabdomyosarcoma (RMS) in 19 (55.9%) patients, germ cell tumor (GCT) in 13 (38.2%), and clear cell adenocarcinoma (CCA) in two (5.9%). Vaginal bleeding was the presenting symptom in 65% of the patients. The 5-year overall survival and event-free survival rates were 73.7% and 77.8%, respectively, in RMS patients. In GCT patients, the 5-year overall survival and event-free survival rates were 84.6% and 61.5%, respectively. One of the two CCA patients died because of disease progression and the other was alive with progressive disease. Conclusions: Primary vaginal tumors are rare in children and generally have a good prognosis. Treatment with chemotherapy only or with either conservative surgery or radiotherapy may achieve an excellent outcome in pediatric primary vaginal RMS and GCT.
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