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Ibrahim, A., Abdel Fattah, O. (2016). The Relation between Mean Platelet Volume/Platelet Count Ratio and Prognostic Factors in Patients with Advanced Non-Small Cell Lung Cancer. Research in Oncology, 12(1), 15-19. doi: 10.21608/resoncol.2016.589
Amal Ibrahim; Ola Abdel Fattah. "The Relation between Mean Platelet Volume/Platelet Count Ratio and Prognostic Factors in Patients with Advanced Non-Small Cell Lung Cancer". Research in Oncology, 12, 1, 2016, 15-19. doi: 10.21608/resoncol.2016.589
Ibrahim, A., Abdel Fattah, O. (2016). 'The Relation between Mean Platelet Volume/Platelet Count Ratio and Prognostic Factors in Patients with Advanced Non-Small Cell Lung Cancer', Research in Oncology, 12(1), pp. 15-19. doi: 10.21608/resoncol.2016.589
Ibrahim, A., Abdel Fattah, O. The Relation between Mean Platelet Volume/Platelet Count Ratio and Prognostic Factors in Patients with Advanced Non-Small Cell Lung Cancer. Research in Oncology, 2016; 12(1): 15-19. doi: 10.21608/resoncol.2016.589

The Relation between Mean Platelet Volume/Platelet Count Ratio and Prognostic Factors in Patients with Advanced Non-Small Cell Lung Cancer

Article 4, Volume 12, Issue 1, June 2016, Page 15-19  XML PDF (530.45 K)
Document Type: Original Article
DOI: 10.21608/resoncol.2016.589
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Authors
Amal Ibrahim email ; Ola Abdel Fattah
Department of Clinical Oncology, Faculty of Medicine, Assiut University, Assiut, Egypt
Abstract
Background: Identifying simple and reliable prognostic indicators in non-small cell lung cancer (NSCLC) is important to optimize its management. The mean platelet volume/platelet count (MPV/PC) ratio may be of prognostic value in some clinical conditions including NSCLC.
Aim: To investigate the relationship between MPV/PC ratio and some important prognostic factors in Egyptian NSCLC patients.
Methods: Retrospective study that included 69 patients with stage III/IV NSCLC in the period from January 2010 to December 2012. The complete blood picture done before starting treatment was the one considered for the calculation of MPV/PC. The relation between MPV/PC ratio and patients and disease characteristics was studied.
Results: More advanced stage was associated with lower average MPV/PC ratio. The average MPV/PC ratio was 0.45963 (95%CI: 0.38829- 0.53098) in patients with stage IIIA, 0.33873 (95%CI: 0.2854-0.39208) in stage IIIB and 0.32752 (95%CI: 0.28642- 0.36862) in stage IV (p=0.015).
Similarly, higher Eastern Cooperative Oncology Group performance status score was associated with lower MPV/PC ratio. The average MPV/PC ratio was 0.40949 (95%CI: 0.34959 – 0.46939) in patients with ECOG 1, 0.36369 (95%CI: 0.31009- 0.41724) in ECOG 2 and 0.28378 (95%CI: 0.24898 -0.31857) in ECOG 3 (p=0.004). Older patients had a significantly lower MPV/PC ratio (p=0.043).
Conclusion: Low MPV/PC is associated with poor prognostic factors in NSCLC such as advanced stage and poor performance status. Future clinical studies to evaluate the prognostic value of MPV/PC ration in NSCLC are warranted.
Keywords
Non-Small Cell Lung Cancer; prognosis; Platelet volume/platelet count ratio
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