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Mousa, S. (2016). Hodgkin Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: A Case Report and Review of Published Cases. Research in Oncology, 12(1), 28-30. doi: 10.21608/resoncol.2016.591
Somaia Mousa. "Hodgkin Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: A Case Report and Review of Published Cases". Research in Oncology, 12, 1, 2016, 28-30. doi: 10.21608/resoncol.2016.591
Mousa, S. (2016). 'Hodgkin Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: A Case Report and Review of Published Cases', Research in Oncology, 12(1), pp. 28-30. doi: 10.21608/resoncol.2016.591
Mousa, S. Hodgkin Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: A Case Report and Review of Published Cases. Research in Oncology, 2016; 12(1): 28-30. doi: 10.21608/resoncol.2016.591

Hodgkin Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: A Case Report and Review of Published Cases

Article 6, Volume 12, Issue 1, June 2016, Page 28-30  XML PDF (414.95 K)
Document Type: Case reports
DOI: 10.21608/resoncol.2016.591
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Author
Somaia Mousa email orcid
Clinical Pathology Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt
Abstract
Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a serious syndrome that occurs in association
with malignancy, infections and autoimmune diseases.
Case presentation: A 30 years old female patient presented with fever, splenomegaly, pancytopenia,
hyperferritinemia, hypertriglyceridemia and hemophagocytosis in bone marrow aspirate. She was initially
diagnosed as HLH. Bone marrow biopsy revealed the presence of Hodgkin lymphoma.
Discussion: The most common HLH associated-malignancy is T/natural killer cell lymphoma and less
commonly diffuse large B-cell lymphoma. The combination of HLH and Hodgkin lymphoma is rare. A strong association between Hodgkin lymphoma associated HLH and Epstein Barr virus (EBV) infection has
been discussed in published case reports. Hodgkin lymphoma may be a cause of HLH and their relation with
EBV has to be investigated.
Keywords
Hemophagocytic lymphohistiocytosis (HLH); Hodgkin Lymphoma; Epstein Barr virus (EBV)
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