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Abdel-Malek, R., Sayed, R., Anis, S. (2018). Isolated Extramedullary Relapse in a Case of Acute Myeloid Leukemia Following Allogeneic Stem Cell Transplantation. Research in Oncology, 14(1), 47-49. doi: 10.21608/resoncol.2018.2231.1041
Raafat Abdel-Malek; Rehab Sayed; Shady Anis. "Isolated Extramedullary Relapse in a Case of Acute Myeloid Leukemia Following Allogeneic Stem Cell Transplantation". Research in Oncology, 14, 1, 2018, 47-49. doi: 10.21608/resoncol.2018.2231.1041
Abdel-Malek, R., Sayed, R., Anis, S. (2018). 'Isolated Extramedullary Relapse in a Case of Acute Myeloid Leukemia Following Allogeneic Stem Cell Transplantation', Research in Oncology, 14(1), pp. 47-49. doi: 10.21608/resoncol.2018.2231.1041
Abdel-Malek, R., Sayed, R., Anis, S. Isolated Extramedullary Relapse in a Case of Acute Myeloid Leukemia Following Allogeneic Stem Cell Transplantation. Research in Oncology, 2018; 14(1): 47-49. doi: 10.21608/resoncol.2018.2231.1041

Isolated Extramedullary Relapse in a Case of Acute Myeloid Leukemia Following Allogeneic Stem Cell Transplantation

Article 10, Volume 14, Issue 1, June 2018, Page 47-49  XML PDF (559.17 K)
Document Type: Case reports
DOI: 10.21608/resoncol.2018.2231.1041
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Authors
Raafat Abdel-Malek email orcid 1; Rehab Sayed2; Shady Anis3
1Clinical Oncology Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt
2Clinical Oncology Department, Arab Organization for Industry Hospital, Cairo, Egypt
3Pathology Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt
Abstract
Background: Acute myeloid leukemia (AML) is the commonest acute leukemia in adults. Allogeneic stem cell
transplantation (ASCT) is a curative option for a subset of these patients.
Case Presentation: We report the case of a 36 years old female patient who presented in April 2014 with pancytopenia.
Investigations revealed that she had AML (M6). She achieved complete remission with induction chemotherapy which was
followed by four cycles of consolidation chemotherapy until a human leukocyte antigen-matched donor was available. She
underwent ASCT in January 2015. After 14 months, in March 2016, she presented with left breast and right
parapharyngeal masses. Histopathological examination of the excised mass showed infiltration with myeloid cells and the
bone marrow was normocellular without leukemic infiltration. She received radiotherapy to the affected breast and the
cervical region followed by chemotherapy with good response.
Conclusion: AML relapse following ASCT may be in the form of isolated Extramedullary disease. Further research is
needed to optimize the management of these cases.
Keywords
Acute Myeloid Leukemia; Allogeneic stem cell transplant; Extramedullary relapse
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